![]() SEP: An electrode on the participant s wrist will give a small electrical shock to test nerve function. TMS: A wire coil placed on the participant s scalp will produce an electrical current to affect brain activity. MEG: A cone over the participant s head will record brain activity. MRI: Participants will lie in a scanner that takes pictures of the body ![]() They study has 3 phases and will last up to 20 weeks. Participants will be inpatients at the Clinical Center. Participants will be screened under protocol 01-M-0254. People ages 22 70 years old who have major depressive disorder and are eligible for ECT To see if iLAST is safe and feasible in treating depression. Researchers want to study a new way to give ECT called iLAST. Although it is effective, it can cause side effects, including memory loss. During ECT, the brain is given electric pulses that cause a seizure. Location(s): National Institutes of Health Clinical Center, Bethesda, Maryland, United StatesĮlectroconvulsive therapy (ECT) is used to treat people with severe depression. Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)Įligibility: 22 Years to 70 Years, Does Not Accept Healthy Volunteers To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort. Healthy controls will complete clinical and neurocognitive measures at one time point. The investigators will also enroll 60 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will study 60 participants aged 21-80 years old with MDD. This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. ![]() ![]() Research Training and Career Development Opportunities.Research Conducted at NIMH (Intramural Research Program).Upcoming Observances and Related Events.Contribute to Mental Health Research Mobile navigation ![]()
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